Regulation of the Citric Acid Cycle by NADH Essay Example

Regulation of the Citric Acid Cycle by NADH Essay Example Regulation of the Citric Acid Cycle by NADH Paper Regulation of the Citric Acid Cycle by NADH Paper Regulation of the Citric Acid Cycle by NADH The Citric Acid Cycle is regulated mainly by the availability of substrates and by feedback inhibition by its products (http://en.wikipedia.org/wiki/Citric_acid_cycle). One such example of product inhibition is the regulation of the cycle by the reduced form of nicotinamide adenine dinucleotide (NADH), three molecules of which are formed in one turn of the cycle. NADH –specifically, a high [NADH] / [NAD+] ratio – also inhibits pyruvate dehydrogenase, which is the enzyme that converts pyruvate to the acetyl-CoA that enters the cycle in its first step. This ratio increases in conditions of fatty acid oxidation, for example, during starvation. The increase in the [NADH] / [NAD+] ratio inhibits the pyruvate dehydrogenase complex, which will then effect into a sparing of carbohydrates. In conditions such as starvation, this sparing of carbohydrates makes sense. Moreover, NADH inhibits the enzymes isocitrate dehydrogenase and ÃŽ ±-ketoglutarate dehydrogenase, which catalyze two of the reactions in which NADH is formed. Along with ATP, which also inhibits the two enzymes, levels of NADH increase when the cell has abundant energy stores. Increased NADH levels, therefore, serve to signal the cell that it does not need to produce as much energy through the citric acid cycle (Champe, Harvey, Ferrier, 2005). Regulation of Fatty Acid Catabolism The catabolism of fatty acids is regulated by several factors, depending mostly on the nutritional status of the individual. This is because fatty acids serve as the body’s major fuel storage reserve (Champe, Harvey, Ferrier, 2005). In starvation states, the low insulin/glucagon ratio favors degradation of fatty acids, usually in the muscle and in the liver. Once the fatty acids are fully oxidized, they yield acetyl-CoA, which are then further processed by the citric acid cycle to yield the energy especially needed by the body during timesof starvation. On the other hand, after a carbohydrate-rich meal, the insulin/glucagon ratio increases. This stimulates fatty acid synthesis, as a way of storing excess energy. When fatty acid synthesis is occurring in the cytosol of the cell, levels of malonyl CoA increase, and this compound inhibits the carnitine shuttle that transports long-chain fatty acids into the mitochondria. Without the carnitine shuttle, fatty acid oxidation cannot proceed and is therefore inhibited (Champe, Harvey, Ferrier, 2005). This is only logical, since the body still has enough energy derived from the carbohydrate-rich meal and does not need the acetyl-CoA that would otherwise have been formed from fatty acid catabolism. Regulation of the Urea Cycle Urea is the form in which amino groups that are derived from amino acids are disposed. When an individual ingests a protein-rich meal, levels of glutamate and arginine increase. Glutamate is added to acetyl-CoA to form N-acetylglutamate, in a reaction that is activated by arginine. In other words, a meal rich in proteins results in increased levels of N-acetylglutamate. N-acetylglutamate, for its part, is an essential activator for carbamoyl phosphate synthetase I, which is the enzyme that governs the rate-limiting step in the urea cycle. It therefore increases the production of urea. In short, a meal rich in proteins – of which amino acids are the building blocks – stimulates, through N-acetylglutamate, the production of urea. This is necessary since urea is the form in which these amino acids are disposed by the body. Thus, this helps maintain the nitrogen balance in the body. References Champe, P. C., Harvey, R. A., Ferrier, D. R. (2005). Lippincott’s Illustrated Reviews: Biochemistry. Philadelphia: Lippincott Wiliams Wilkins. Citric Acid Cycle. (2008). In Wikipedia, the free encyclopedia. Retrieved October 7, 2008, from Wikipedia: http://en.wikipedia.org/wiki/Citric_acid_cycle

Translatory

Translatory Translatory Translatory By Maeve Maddox This reader’s question relates to the word translatory. Before writing, he looked it up:    Merriam-Webster definition: â€Å"of, relating to, or involving uniform motion in one direction.† Nothing about its clear parallel, translate. The Free Dictionary lists â€Å"translatory as an adjective under its entry for translation. Oxford does not appear to list it as a word at all – at least via online search. Translational is likely the correct adjective to use when discussing a translation, although translatory has been used to mean translational (e.g., ‘the translatory pen of William Tyndale’).    Ah, the ongoing battle of the dictionaries. The Merriam-Webster Unabridged I pay for has an entry for translatory, but no definition, just a link to translational. The OED I use via subscription does have an entry for translatory: â€Å"of or pertaining to physical translation† and offers this example from 1849: â€Å"The negative tension of an insulated metal is sensibly augmented by giving a translatory motion to the gas which attacks its surface.† M-W has a separate entry for â€Å"translatory motion†: â€Å"motion in which all points of a moving body move uniformly in the same line or direction.† No example of usage is offered. The short answer to the reader’s question is that some speakers may use translatory in reference to translating languages, but translational is the more common adjective in that context. A cursory search of the Web brought up two uses of translatory in reference to the translation of language, both from non-native English-speaking sources: The  master’s programmeprovides in-depth knowledge of (foreign) languages and translatory skills acquired in the bachelor’s programme.- University of Graz (Austria). [Some translators] failing to see the larger context or the  translatory  action at work.- Literary Translation in Modern Iran: A sociological study, by Esmaeil Haddadian-Moghaddam. A search for â€Å"translatory† on Google brings up the admonitory message: â€Å"Did you mean translator?† and Word flags the word translatory with a squiggly red line. The words translate, translator and translation have different meanings in different contexts. For me, a translation is a text written in a language other than the original, and a translator is someone who renders a work written in one language into another. In another context, a translator is a transmitter that rebroadcasts the signals of a distant TV station to rural areas: In 1973, the construction of a network of transmitters and translators connected by microwave relay was approved by the state legislature. Another meaning of translate is â€Å"To change in form, appearance, or substance.† Peter Quince uses the word with this meaning in A Midsummer Night’s Dream when, like Snount, he reacts to the sight of Bottom with an ass’s head: SNOUT: O Bottom, thou art changed! What do I see on thee? BOTTOM: What do you see? You see an ass head of your own, do you? QUINCE: Bless thee, Bottom, bless thee. Thou art translated. Translatory has its uses, but it is not the conventional choice in the context of language translation. Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Vocabulary category, check our popular posts, or choose a related post below:100 Exquisite AdjectivesDeck the HallsHow to Style Legislative Terms

Endocrinology Essay Example | Topics and Well Written Essays - 1000 words

Endocrinology - Essay Example These are synthesized in the same cells. However, once secreted they interact with four adrenergic receptors such as 1, 2, 1, 2, and 3 that mediate the cellular effects of the hormones. Stress the predominant stimulus that leads to secretion of these hormones. More accurately stimuli such as injury, anger, pain, cold, strenuous exercise, and hypoglycemia as a result of stress response generate sympathetic impulses in the cholinergic preganglionic fibers that provides the neural impetus to the chromaffin cells, and this ultimately culminates into the release of catecholamines. Biochemically, however, catecholamines stimulate glucose production in the liver, lipolysis in the adipose tissue, and promotes anaerobic metabolism in the muscles leading to lactate production. Whereas, the adrenal medulla responds to predominantly neural stimuli, the outer adrenal cortex that literally encapsulates the medulla and forms the bulk of the gland, responds only to endocrine stimulation and releases a number of hormones which have steroid structures chemically. These hormones are glucocorticoids, aldosterone, and adrenal androgens. The cells of the three zones secrete different steroid hormones: the cells of the zona glomerulosa secrete the mineralocorticoids; those of the zona fasciculata secrete glucocorticoids, while the cells of the zona reticularis secrete sex steroids or androgens (Brook, C., and Marshall, N. 2001). Figure 1: Adrenal Cortex and Medulla Adrenal Cortex: Glucocorticoids act to counteract many effects of stress throughout the body. Stress is difficult to define, but it is known that it includes physical trauma, intense heat or cold, infections, mental or emotional trauma. The effects of glucocorticoids at the tissue level in order to neutralize the effects of stress include cardiovascular, neurological, and anti-inflammatory effects as well as effects on the immune system. Cortisol level responds within minutes to stress, whether it is physical such as trauma, surgery, or exercise; psychological such as anxiety and depression, or physiological hypoglycaemia or fever. The protective effect that glucocorticoids confer at the time of stress would be evident in the observed fact that such stresses may cause hypotension, shock, and death when there is glucocorticoid deficiency. The overall actions of glucocorticoids are directed at enhancing the production of glucose that can be readily utilised in the body to produce energ y and at the same time they reduce all other metabolic activities not directly involved in that process. Physiologic effects of glucocorticoids include regulation of protein, carbohydrate, lipid, and nucleic acid metabolism. These antagonize the secretion and action of insulin and raise blood sugar levels. At the same time, these also inhibit peripheral glucose uptake. This promotes hepatic glycogen content through hepatic glucose synthesis or gluconeogenesis (Berg, J.M., Tymoczko, J.L., and Stryer, L., 2002). Taking the example of exercise as a stress initiating event, as the epinephrine and nor epinephrine are released as a sympathetic response, the concomitant glucocorticoid release makes sure that the increased metabolic rate of exercise can

Third World Country Term Paper Example | Topics and Well Written Essays - 2000 words

Third World Country - Term Paper Example eastern beliefs and practices and resulted to a culturally conservative but socially dynamic people who has always preserved the rich native culture but opened its arms to the influences of the west. The National Statistics Office (NSO) of the Philippines reported that its population is at 88.57 million as of August 2007. The National Capital Region (or more popularly called Metro Manila), where the capital city of Manila is situated has 11.55 million, the second largest populated region while the two regions adjacent to the National Capital Region are the 1st and the 3rd largest. The combined number of residents of these three regions already comprised more than one third of the entire population at 37.3% (Ericta, 2008). The Philippine economy had been sluggish compared with its other south east Asian neighbors, however the year 2007 showed indications of a stronger economy when it posted an average real growth rate in gross domestic product (GDP) of 7.3%, by far the highest in 31 years (WHO regional office, 2009). However, poverty statistics showed a 2.5 percentage points increase in poverty rate from â€Å"4.7 million poor families in 2006 compared with 4.0 million estimated in 2003† (WHO, 2009) thus the World Health Organization regional office in the western pacific surmised that the economic challenge is to trickle down the signs of economic progress to the poor sector of the population in order to alleviate poverty (WHO, 2009). Henderson reported that â€Å"poverty in the Philippines is most acute and widespread in rural areas (2002)† but Metro Manila, has the lowest occurrence of this nationwide phenomenon, where there are only 5% of the nations poor. He also conveyed how worse the situation is especially when translating the conditions in monetary value. The Filipino below the poverty line earns â€Å"less than $276 a year (...) considered the minimum required to meet basic living requirements† (Henderson, 2002). Culturally, the Filipinos adhere to

Models of Addiction Essay Example for Free

Models of Addiction Essay The addicted person can be a composite of patterns of behavior, predisposition, and social environment. Generally, he is preoccupied with the substance or behavior of choice and will continue to practice the addiction in increasing amounts of time and material. Cessation results in withdrawal symptoms and discomforts both physically and psychologically. In spite of attempts to cut back or cease the activity, the addict will continue to his behavior to his own detriment and destruction. There are many factors that need to be considered when addressing causation, allowing the models of addiction to fall into three basic categories; medical, social, and psychological. Medical Models This model rests on the assumption that disease states are a result of a biological dysfunction, possibly one on the cellular or even molecular level (Doweiko, 2012). The disease or dispositional concept allows the addict to bear no responsibility for the addiction (Jenkins, 2014). Because of underlying physical abnormalities, the addict is not able to control the use of the substance or his behavior. This is the primary way of viewing addictions in the United States, according to Doweiko (2012). The cause here is considered biological or hereditary. A problem here is the potential for denial of personal responsibility. Genetic factors consider vulnerability, predisposition, and how genes come together to increase risk for addiction. Patterns over time and generations can be helpful in research and in understanding possible solutions. This idea is limited in that research is narrowly focused on biological and genetic factors versus other factors.   Social Models This model views peer pressure, social policies, and availability as major contributing influences surrounding addictions. It is mainly concerned with conformance and deviance, what helps, and what is a risk. Unhealthy relationships, dysfunctional families, and environment play a major part in the cause of addiction in this type of model (Jenkins, 2014). Inadequate coping mechanisms and vicarious learning contribute to the problem. The focus is on family, peers, personal relationships, and learned behaviors. The moral volitional or willful sin theory relies on social sanctions to remedy addiction and sees it as a weakness of character. The greatest hope here is that changing peers, places, and things offers recuperation. On a spiritual level, the degrading effects of sin illuminate the need for redemption (Jenkins, 2014). This compulsion is seen as a form of idol worship, as it places the obsession before God. It hinders spiritual growth and alters the image of God within the believer. Social models are limited in that relationships are difficult to measure (Jenkins, 2014). Rather than how the addiction develops, the emphasis is on recovery. Genetic predisposition and other areas are not taken into account or ignored and the individual’s ability to resist is not contemplated. Psychological Models With the rise of psychoanalysis came the psychological models of addiction. The addict is considered as being immature developmentally and as having fundamental traits that contribute to the problem. There is the belief that the dilemma is reinforced both socially and MODELS OF ADDICTION 4 environmentally creating a learned response through classical and operant conditioning (Jenkins, 2014). It is thought that the addict uses defense mechanisms to remain in denial about his predicament and will use cognitive justifications for otherwise unacceptable behavior (Doweiko, 2012). Conclusion From the various models used to understand and explain addiction, it is  apparent that there is an overlapping or interconnection among the theories. This would support an integrated approach to identifying the cause and effects of this problem. When all factors are considered, the puzzle is much easier to put together. Treatment can then be comprised of multiple options and resources making recovery more attainable. References Doweiko, H. 2012. Concepts of chemical dependency , 8th ed. Belmont, CA: Brooks/Cole, Cengage Learning Jenkins, D. 2014. Presentation: Models of addiction. Retrieved from http://learn.liberty.edu.

H.M. Scott Smiths, the Historical Houses of Prince Edward Island :: essays papers

H.M. Scott Smith's, the Historical Houses of Prince Edward Island H.M. Scott Smith's, the Historical Houses of Prince Edward Island, is a candid look into the more architecturally and historically significant buildings located on Prince Edward Island. Focusing particularly on those constructed in the 19th and early 20th centuries, Historical Houses of Prince Edward Island, features structures from the early days of the Micmac wigwams to the elegance of the Victorian presence. His purpose is to trace the evolution of the Islands housing in their form, decor, and construction over the course of time. In addition, Smith writes of the different principal international impacts, which have shaped the architectural stature of Prince Edward Island. Hoping to set a starting point in Prince Edward Islands' architectural studies, Smith states 1"I also wish to stress that I conceived this project and these books as a beginning, in the hope that architectural historians, geographers, academics or any interested individuals might be inspired to further research and document the various aspects touched on only briefly in this book." Smith, an active conservationist, clearly shows that he believes in the importance of building history and preservation, not only in Prince Edward island, but all over the world in hoping that others will pick up where he has left off opening another door in architectural studies. Smith provides the reader with an easy to follow guide, which is set in Smith, H.W. Scott. Historical Houses of Prince Edward Island. Erin: Boston Mills Press, 1990. P.10 chronological order and provides, photographs and/or sketches with each brief, yet descriptive, explanation of the chosen dwellings. Expressive yet not overpowering, we are taken through the evolution of the selected structures by means of the change in style and heritage from that of the architectural monuments origin. In the journey of seeking architectural history, the author touches on, but hesitates to go in-depth with the true mode of building based on regional forms and materials. The lack of information covering the social and community history, building placement, along with the unique building styles (with stone and brick) formed by the adapting peoples of the Island leaves a lot out of this book. Instead, Smith focuses intensely on the inhabitants of the homes throughout time, and the strong foreign influence from Scotland, England, Ireland, and New England. The glossary, which Smith provides, was very effective as it made his work easy to understand while increasing the readers knowledge of architectural terms.

Measuring Crime Essay

There are so many different police agencies and levels here in the United States. Here are a few of the Federal policing agencies: Department of agriculture, commerce, Defense, FBI, and justice, but there are 15 Federal departments. The State level agencies consist of highway patrols, port authorities, state police, fish and wild life police which are only a few of the state levels agencies. At the local level agencies, there are campus, constables, transit police, and sheriff’s department, which also are just a small portion of the local level agencies. With so many policing agencies, we measure the crime level here in the United States with three main tools. â€Å"They are uniform crime report, National crime victimization survey, and the National incident based reporting system. The uniform crime report: Law enforcement agencies voluntarily report crime statistics on a monthly basis to the FBI. Areas of interest are murder, burglary, forcible rape, robbery, aggravated assault, larceny/theft, auto theft and arson. The National victimization survey is conducted by the Bureau of Justice statistics; the survey is conducted every six months on all household members 12 and older to help determine the magnitude of illegal unfair treatment-mainly unreported victimization. The National incident based reporting system is new and currently being tested and evaluated. This system will eventually replace the uniform crime report. Additionally, this report will expand the list of crimes for which data is collected† (University of Phoenix, 2013). Major crime reporting programs and purposes In the United States, there are several modes of crime reporting that assist lawmakers, citizens, and criminal justice officials with accurate information regarding various crimes. The three major programs are the National Incident Based Reporting System (NIBRS), Uniform Crime Reports  (UCR), and National Crime Reporting (NCR). Each reporting system serves a direct reporting purpose that has advantages for some and disadvantages for others. The three crime reporting systems have distinct origins that details the need for the creation of each system while providing justification for its longevity. The three major crime reporting systems are feasible for people trying to gain information on crimes and will be relevant until more intricate systems exist. â€Å"The objective of the Uniform Crime Reporting program is to produce crime statistics for law enforcement administration, operation, and management† (Texas Department of Public Safety, 2014). UCR is a national administrative program that uses collaboration between, states, counties, and federal law enforcement agencies to publish criminal statistics. Although effective, the UCR is not 100 percent accurate because all departments do not report criminal data to the program. The NIBRS focuses on incidents and arrests as opposed to crime completely and the information is generated by local, state, and federal agencies. National Crime Reporting is a program that shows the crime statistics of the nation. It is an index of information that is available to federal, state, and local authorities. The major purposes of crime reporting programs are to provide senior officials with an accurate snapshot of crime data that fluctuates. The data has many purposes to many people like city officials who use the data to place emphasis on certain crimes. The data is also important to media and public citizens who use the information to conduct research or shop for homes. Though the information is mostly accurate, the Federal Bureau of Investigations discourages negatively using the information to depict a region, state, county, or city. There are numerous factors that influence the fluctuation of certain crimes in different areas so using common sense to decipher the sociological factors is necessary. References Texas Department of Public Safety. (2014). The Texas uniform crime reporting program. Retrieved from http://www.txdps.state.tx.us/administration/crime_records/pages/ucr.htm University of Phoenix (2013) Interactive Multi-Media CJI Link [Multimedia]. Retrieved from University of Phoenix, CJA-204 website

Bacon

â€Å"Of Studies† by Francis Bacon An analysis The purpose of this work is to analyze Sixteen Century Francis Bacon’s essay â€Å"Of Studies† by summarizing its main points and the relevance of its statements to this day. Francis Bacon was an English Philosopher and writer best known as a founder of the modern empirical tradition based on the rational analysis of data obtained by observation and experimentation of the physical world. The main focus of Bacon’s essay rests on explaining to the reader the importance of study knowledge in terms of its practical application towards the individual and its society.His first analysis is an exposition on the purposes or uses that different individuals can have by approaching Study –â€Å"†¦for delight, ornament, and for ability†- And how certain professions are better served by individuals with study knowledge. As he mentions the virtues of Study he also points out its vices: –â€Å"To sp end too much time in study is sloth†¦Ã¢â‚¬  Also, how Study influences our understanding of Nature, and in opposition, how our experience of Nature bounds our acquired knowledge.After that, the Author presents the concept of how different individuals with different mental abilities and interests in life, approach the idea of studying –â€Å"Crafty men contemn studies†¦Ã¢â‚¬ - and offers advice on how study should be applied: –â€Å"†¦but to weight and consider†- Then Bacon goes into expressing his ideas in how the means to acquire study knowledge, books, can be categorized and read according to their content and value to the individual. The benefits of studying are Bacon’s final approach.Benefits in terms of defining a â€Å"Man† by its ability to read, write or confer, and in terms of being the medicine for any â€Å"impediment in the wit† and by giving â€Å"receipts† to â€Å"every defect of the mind†. Cert ainly, some of Francis Bacon’s insights in this subject are of value after 400 years of societal evolution. We can ascertain this when we read the phrase â€Å"They perfect Nature, and are perfected by experience†¦Ã¢â‚¬  Nevertheless some of the concepts expressed in his Essay have to be understood through the glass of time.By this I mean Society values and concepts were different altogethers to what we know today. By that time Society was strongly influenced by the idea of literacy and illiteracy (relatively few were educated and could read and write). Only educated people had access to knowledge and by that, to social status and opportunity. Nowadays would be difficult to accept ideas which relate skills or professions towards an attitude to approach studying. Today, a skilled machinist or carpenter can certainly be a studied person.Nowadays most people in our Society have the possibility to read and by that, to obtain knowledge independently of what our personal cho ices are in terms of profession. Also we must consider how today we value the specialization of knowledge which in the past, characterized by a more generic and limited access to knowledge, wasn’t a major factor into the conceptualization and understanding of study knowledge as to the extent we see it today. Finally, it is doubtful that the benefits of studying can be approached as a recipe for any â€Å"intellectual illness†.We now know that the real illnesses are related to mental conditions and not necessarily to our mental skills, abilities or lack of them and by that I mean that Bacon’s solutions to those conditions are substantially naive under the actual understanding of Human Psychology. Concepts and ideas evolve at the same time as the Human condition changes in all social, scientific, political and economic aspects. By looking through the glass of time and comparing the past to the present we come to the realization of the universality and endurance of some concepts and the fragility and impermanence of some others.

Republican Women in the US Senate 2017â€2019

Republican Women in the US Senate 2017–2019 Five women represent Republicans as senators in the 115th Congress, running from 2017 through 2019. The number is one fewer than for the previous Congress as New Hampshires Kelly Ayotte lost re-election by only about 1,000 votes. Alaska: Lisa Murkowski First Elected: 2004 (Appointed in 2002 to fill a vacancy)Next Election: 2022 Lisa Murkowski is a moderate Republican from Alaska with a roller-coaster history. In 2002, she was appointed to the seat by her father, Frank Murkowski, who vacated it after being elected Governor. This move was viewed unfavorably by the public and she barely won her first full term in 2004. She won the seat by just 3 points on the same day George W. Bush won the state by more than 25 points. After Sarah Palin routed her father in the 2006 Gubernatorial primary, Palin and conservatives backed Joe Miller in 2010. Though Miller beat Murkowski in the primary, she launched a surprisingly successful write-in campaign and ended up winning a close three-way race. Iowa: Joni Ernst First Elected: 2014Next Election: 2020 Joni Ernst. Getty Images   Joni Ernst was the surprise candidate of the 2014 election cycle as she handily won the US Senate seat vacated by long-serving Democrat Tom Harkin. Democrat Bruce Braley was supposed to be the easy winner, but Ernst played to her Iowa roots and got off to a fast start after running a television spot comparing the castration of pigs to cutting pork in Washington. Ernst is a lieutenant colonel in the Iowa National Guard and had served in the Iowa State Senate since 2011. She won her US Senate seat in 2014 by 8.5 points. Maine: Susan Collins First Elected: 1996Next Election: 2020 Susan Collins is a moderate Republican from the Northeast, one of the few remaining as liberal Democrats have steadily increased their hold in the region. She is socially liberal and center-right on economic issues and she was a strong advocate for small businesses prior to her career in the US Senate. Collins is easily the most popular figure in the state and has seen her vote share increase in every election since 1996 when she won with just 49 percent of the vote. In 2002, she won with 58 percent of the vote, followed by 62 percent in 2012, then 68 percent in 2014. In 2020, she will be 67 years old and Republicans hope she stays around a bit longer. Nebraska: Deb Fischer First Elected: 2012Next Election: 2018 Deb Fischer represented one of the few highlights in the 2012 election for both conservatives and the Republican Party. She was not expected to be a contender in the GOP primary and was heavily outspent by two higher-profile Republicans in the state. Near the end of the primary campaign, Fischer received the endorsement of Sarah Palin and subsequently surged in the polls, landing a surprise win in the primary. Democrats saw this as an opening for former US Senator Bob Kerrey, who held the seat as recently until 2001. But it wasnt meant to be for the Democrats, and she defeated him in the general election by a landslide. Fischer is a rancher by trade and served in the state legislature since 2004. Senators Deb Fischer (lower center) and Shelley Moore Capito (above) celebrate passing the Tax Cuts and Jobs Act. Getty Images West Virginia: Shelley Moore Capito First Elected: 2014Next Election: 2020 Shelley Moore Capito served seven terms in the US House of Representatives before deciding on a run for the US Senate. At the time, five-term Democratic incumbent Jay Rockefeller had not yet announced his plans. He opted for retirement rather than face the first real challenge of his career in more than two decades. Capito easily won both the Republican primary and the general election, becoming the first woman elected to the US Senate in West Virginia history. She also won a Senate seat for the GOP for the first time since the 1950s. Capito is a moderate Republican, but a solid upgrade from the 50-plus year drought for conservatives in the state.

The Demise of De Luxe

The Demise of De Luxe The Demise of De Luxe The Demise of De Luxe By Maeve Maddox In a conversation about hotels the other evening, I heard a woman say â€Å"the lobby was luxe.† I’d never heard luxe without the de. At least not in English. In the French expression the de is a preposition and the luxe is a noun, literally â€Å"of luxury.† In English wed say luxurious. Following French usage, the OED entry gives de luxe as two words and classifies it as an adjective phrase. Merriam-Webster spells deluxe as one word and defines it as â€Å"notably luxurious or elegant; sumptuous or elaborate.† Booksellers have long offered deluxe editions of popular books and the label has spread to other products: The terms special edition, limited edition and variants such as deluxe edition, collectors edition and others, are used as a marketing incentive for various kinds of products, originally published products related to the arts, such as books, prints or recorded music and films, but now including cars, fine wine and other products. Wikipedia Apparently just plain luxe enjoys wide popularity. Numerous hotels call themselves Luxe Hotel. Luxe and deluxe bump up against each other in newspaper coverage, for example this story in the San Francisco Business Times uses â€Å"luxe† in the headline and â€Å"deluxe† in the story S.F. tower to become luxe hotel (headline) Partners will likely shell out an additional $500 a square foot to convert it from an empty ATT office to the deluxe downtown destination. I came across a hotel site (Maddens on Gull Lake) that offers luxury accommodations, premium accommodations and deluxe accommodations. The word luxe derives from Latin luxus, â€Å"excess† or â€Å"abundance.† I plan to keep putting a de with my luxe. Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Misused Words category, check our popular posts, or choose a related post below:10 Rules for Writing Numbers and Numerals"Latter," not "Ladder"The Difference Between "Un-" and "Dis-"

Religious Conflicts in Lebanon Essay Example | Topics and Well Written Essays - 2500 words

Religious Conflicts in Lebanon - Essay Example Moreover, there is conflict between the Sunni Muslim majority and the Shiite Muslim minority who been engaged in conflict for a long time and up to date, they are not at peace with each other. The Druze is another distinct fraction in Lebanon, they are also the minority in Lebanese society, and they have been into conflict with the Christians in the 1840s when the country was known as Mount Lebanon. Until today, there is tension between these religious groups as they are trying to build a stable democracy. It can be therefore noted that the chaos among religious groups in Lebanon is as a result of failure to establish a working power sharing system between these groups. This paper explores the religious conflict in Lebanon and it is organized in three sections. The first section presents sectarianism in Lebanon, followed by an analysis of the root of the conflict, identifying the actors and their interests. Lastly, the paper discusses possible solutions and consequences of different policy solutions. Mostly, the conflict in Lebanon is presented as a sectarian conflict, which involves the moderate Christians and the extremist Muslims (â€Å"Troubles a test†¦Ã¢â‚¬ ). Apart from religious differences between the Christians and the Muslims, there is also conflict within the Muslim community, between the Sunnis and the Shiites. The Muslim society was divided in Sunni and the Shiite because of the power struggle over succession (Tomass 714). The entire population including the Christians and Muslims speak Arabic language; however, sectarianism is a dominant socio-political reality in Lebanese society despite the features they have in common. Sectarianism is not a new in Lebanon, historical Lebanon also called Mount Lebanon used to be shared mainly by Druzes and the Maronites. They did not coexist in peace and harmony as they fought over land ownership and distribution of political power among other issues. But these two groups have coexisted in harmony until the

OUTLINE THE METHODS USED IN LANGUAGE LEARNING AND COMMENT ON THE Essay

OUTLINE THE METHODS USED IN LANGUAGE LEARNING AND COMMENT ON THE SUCCESS OF EACH - Essay Example This article speaks of various language learning methods and their success on implementation. This is one of the oldest methods known to have got developed by British applied linguistics in the late 1930s and 1960s. It does not have prominence in present day language learning methodology. The theory behind the language says that structural view of the language is the basis. It stresses more on the process and behaviorism. The basic principles are: In this way the language is learnt at a very slow pace. Learning the language on the basis of structure alone will almost take an academic year to master. But, once the language is learnt through patience learners are expected to get expertise in the written knowledge as well. This is one of the most popular methods of learning a language in 1950s and 1960s. It is still preferred by various Educational Institutes and language teaching centers. The theory for its foundation is again the structural view of the language. Getting expertise in the building blocks of the language and then laying emphasis on rules to join them to make a meaningful statement. The key points that elaborate on the theory are similar to those of situational language learning. In this method of learning, the language is learnt in its true accent. The procedures when properly implemented make the learners speak the language in its true jargon and apply the words at apt situations. This method of learning came into existence in 1960s as a replacement to the above two methods which have their theory based on the structural view of the language. The theory on which it is formatted is the functional view of the language. Principles that govern this method are: Learning is enjoyable and delivers good results once it is done through real communication. Learning is based on activities that clearly put in front the real essence of the language i.e. if a particular